By bringing the entire body to a temperature of 41.5°C for multiple hours, a cytotoxic effect is achieved, which is stronger in cancer cells. Exposure to heat also increases their sensitivity to chemo- or radiotherapy through a combination of physiological mechanisms.
For a safe and successful treatment, it is essential to accurately monitor and control the temperature throughout the body. ElmediX’ device can precisely regulate the patient’s body temperature combining state-of-the-art thermal sensing catheter data with a proprietary thermal model of the human body.
Building on successful preclinical results obtained through in vitro and in vivo experiments, demonstrating safety and efficacy, a first-in-human clinical trial will be initiated in Q2-Q3 2020.